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Appus is natural protein/peptide animal tissue extract at preclinical stage of development with a following data:
- non-clinical safety studies: positive acute toxicity evaluation on rats with 50x time overdosing
- hypothetical mechanism of action: IL -10 up regulation by factor x10 and TNF -alpha level downregulation by 40-50% at ex vivo induced human PBMC cells.
- Indications:
- over 40% reduction of pathological score at collagen induced mouse model of RA
- positive, anecdotal observations at MS and ALS volunteers (delivery per os).
- >90% efficacy at pilot clinical trials at dogs Pyometra treatment.